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Nephral Plus

Nephral Plus

is a nutritional supplement which is completely natural product, a combination of several highly purified naturally available terpenes.

Nephral Plus  ingredients and its pharmacological action :

Ingredients Effect
Pinen Diuretic, antibacterial
Camphene Hyperemic, Choleretic, antibacterial, spasmolytic
Borneol Choleretic, vasodilatory, antibacterial, analgesic, spasmolytic
Polyoxeythylene sorbitan monooleate Improves solubility of solid particles (Increases calcium solubility)
Vitamin A vitamin A prevents the enzymatic degradation of  important urinary crystallization inhibitors necessary to inhibit stone formation.
Vitamin B6 ( pyridoxine) vitamin B6 may decrease oxalate production and  reduce the risk of kidney stone formation.

Indications of Nephral Plus

1

Supports the normal physiological function of kidneys and the urinary system.

2

Assists in the dissolution of existing urinary tract stones and helps to prevent new stone formation.

3

Assists in maintaining normal solubility of calcium salts and other particles in the urinary tract.

4

Relieves pain , spasm , discomfort associated with urinary tract stones ( spasmolytic), thus assisting the passage of stones.

5

Can be successfully combined with lithotripsy (before and after lithotripsy).

6

Has urinary tract diuretic function.
Logo 1

European Urology Supplements

  • Stone Clearance:

    Improving Stone Clearance after Extracorporeal Shock Wave Lithotripsy in Urolithiasis Patients by a Special Terpene Combination: Results of a placebo-controlled, Randomized Trial. Vol.9. Issue 12 Dec. 2010
    N= 222 Urolithiasis patients.

  • Duration of study:

    June 2003 and December 2006, Clinically unapparent kidney or ureter stones who had undergone complication-free ESWL. All patients underwent physical examination, and the diagnosis of kidney stones was made by x-ray, intravenous pyelogram (1VP), or ultrasound at weeks 1, 4, 8, and 12 as well as after 2 weeks of follow-up.

  • Intervention

    Patients were randomized to receive either 3×2 terpene combination capsules per day or placebo.

  • Results:

    Significantly more patients treated with the terpene combina­tion were stone free at the end of the study compared to placebo  (intention-to-treat 72 patients [67.9%] vs 49 patients ; p = 0.0009; 69 patients [78.4%] vs 48 patients [52.2%]; p = 0.0004) 72 patients [67.9%] vs 49 patients [50.0%] ( terpene combination vs placebo).

    The terpene combination treatment significantly reduced the median time to stone-free status 85.0 days vs 56.0 days (terpene combination vs placebo).
    Improving Stone Clearance after Extracorporeal Shock Wave Lithotripsy in Urolithiasis Patients by a Special Terpene Combination: Results of a Placebo-Controlled, Randomized Trial. Vol.9. Issue 12 Dec. 2010.

Logo 2

Department of Urology, Hanyang University College of Medicine, Seoul, Korea

  • N=

    499 Urolithiasis patients.

  • Duration of study:

    January 2009 to August 2012.

  • Group 2:

    consisted of patients who were prescribed only an analgesic and Tamsulosin 0.2 mg.

  • Group 1:

    consisted of patients who were prescribed an analgesic, Tamsulosin 0.2 mg, and terpene combination.

After 4 weeks of treatment:

comparison of expulsion rate(%)

  • Group 1a
  • Group 2b

2 weeks: Cumulative expulsion rate 2 weeks after first SWL,

4 weeks: Cumulative expulsion rate 4 weeks after first SWL.

a : Taken NSAIDS, Tamsulosin 0.2 mg and Terpne’s combination.

b: Taken NSAIDS and Tamsulosin 0.2 mg. NSAID, nonsteroidal anti-inflammatory drug; SWL, shock wave lithotripsy

Study groups Expulsion rate of stone (p=0.022) Ureteroscopic removal of stone (p=0.756)
Group 1 72.2% 15 patients (10.2%)
Group 2 61.1% 40 patients (11.4%)

The Effect of Terpene Combination on Ureter Calculus Expulsion After Extracorporeal Shock Wave Lithotripsy, Dai Hee Kim, Hyeok Jun Goh, Ho Won Lee, Kyu Shik Kim, Yong Tae Kim, Hong Sang Moon, Seung Wook Lee, Sung Yul Park.

Indian Journal of Clinical Biochemistry

1

Effect of pyridoxine (Vitamin-B6) supplementation on calciuria and oxaluria levels of 20 normal healthy persons and 17 urinary stone patients has been studied.

2

Mean 24 hour urinary calcium and oxalate levels of controls (healthy persons) and stone patients were estimated in pre-supplementation period and at every 20 days interval during supplementation.

3

Stone patients were divided into two groups viz., mild hyperoxaluriacs and moderate hyperoxaluriacs, based on their pre-supplementation (base line) oxaluria levels.

4

60 days of pyridoxine supplementation, at the rate of 10 mg/day, resulted in a significant decrease (p<0.01 for mild hyperoxaluriacs and p<0.001 for moderate hyperoxaluriacs) in mean 24 hour urinary oxalate levels of urinary stone patients

Clinical efficacy of Nephral Plus

  • Promotes disintegration of stones
  • Forced stone expulsion: expulsion rates are higher and accelerated
  • Impact on symptomatic improvement: high number of improved symptoms in treated patients.
  • Promotes relief of frequency and urgency associated with mild urinary tract infection.
  • Excellent safety profile: no or only mild adverse reactions in response to treatment
  • Prevention: anti-lithogenic effect leads to decreased oxalic acid concentration, calcium oxalate formation and calcium content in renal tissue
  • Pharmacodynamics: represent a multi-targeted terpene action which covers the pathophysiological situation.

Ingredient ( per servings):

  •  Polyoxyethylenesorbitan mono-oleate :165mg.
  •  Silver Fir essential Oil(Abies Alba oil) with content of : Alpha pinen, Beta pinen, camphene, car-3-ene, limonene, bornylace tate , borneol : 45mg.
  •  Vitamin A (retinyl palmitate): 4500 IU.
  •  Vitamin B6 ( pyridoxine): 9mg

Directions:

For adults and children over 14 years of age, take 3 soft gels daily, preferably before meals or as directed by your doctor. Do not exceed the recommended daily dose.

Adverse Effects:

Occasionally patients complain of slight transient gastric disturbance.

WARNINGS AND PRECAUTIONS :

Nephral Plus should not be used in patients taking oral anticoagulants or other drugs metabolized by the liver where the dose is critical and in severe renal colic or infection of the urinary tract and in patients with anuria/ renal failure.

Pregnancy and Lactation: Nephral Plus should not be used in pregnant women and in mothers who are breast feeding**.

60 Oval Soft gelatins in a blister package.

**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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